Aside from the Cagayan Special Economic Zone which host casinos and other gaming facilities, scenic spots and historical landmarks are present in this town. These include:
- Cape Engaño Lighthouse/Cove (USA Survivor 27 and 28 filming area)
- Siwangag Cove (USA Survivor 27 and 28 filming area)
- White beaches like Anguib Beach, Mapurao Beach, Nangaramoan Beach, and Puzo Robo Beach
- Gotan mangrove forest and waterfalls
- Suncity Casino in Barangay Tangatan
- Buacag Falls at Santa Clara (temporary closed), Padlas Falls at Casambalangan, Lamesa Falls at Casagan (not yet ready for public)
- Sinago Cove
- Dumasag River at Rapuli
- Riding Takuli (a traditional kayak)and firefly watching at Barangay Casagan
Santa Ana is the Game Fishing hub of the Philippines. It has hosted international decathlons, where athletes run through the rugged terrain of Punta Verde to Cape Engaño, then dipped in the crystal clear water of the Philippine Sea.