Sant'Onofrio is a comune in the Province of Vibo Valentia in the Italian region Calabria, located about 45km southwest of Catanzaro and about 4km northeast of Vibo Valentia. As of 31 December 2004, it had a population of 3,202 and an area of 18.4km2. It is named after Saint Onuphrius. Sant'Onofrio borders the following municipalities: Filogaso, Maierato, Pizzo, Stefanaconi, Vazzano, Vibo Valentia.