Santa Margherita di Belice (Sicilian: Santa Margarita) is a town in the Province of Agrigento in the Italian region of Sicily. It lies in southwest Sicily, 400m above sea level, near where the borders of the Province of Agrigento, Province of Trapani and Province of Palermo meet. It is approximately 60km southwest of the city of Palermo, 60km northwest of the city of Agrigento and sits in the Belice valley among the rivers Belice, Senore and Carboj.
