Salisbury House in Des Moines, Iowa is a Tudor, Gothic and Carolean style manor home. It was built by cosmetic magnate Carl Weeks and his wife, Edith Van Slyke Weeks, between 1923 and 1928. Salisbury House was modeled after the King's House in Salisbury, England, contains 42 rooms and measures just over 22,000sqft. The property is owned and operated by the Salisbury House Foundation and is open to the public for tours, public events, and private rentals.
Salisbury House was added to the National Register of Historic Places in 1977. The listing covered a 9.4acre area with two contributing buildings, one other contributing structure and one contributing site. Salisbury House is also on the List of Registered Historic Places in Iowa.