Oranienburger Straße is a street in central Berlin, the capital of Germany. It is located in the borough of Mitte, north of the River Spree, and runs south-east from Friedrichstraße to Hackescher Markt.
The street is popular with tourists and Berliners for its nightlife with numerous restaurants and bars. Formerly a centre of Jewish life in Berlin, the street contains the restored New Synagogue. Another tourist landmark was the Kunsthaus Tacheles, an alternative art center and night club. Oranienburger Straße is also known for relatively prominent street prostitution, which is legal in Germany.
There are also two lesser known streets named "Oranienburger Straße" in Berlin, in Reinickendorf and in Lichtenrade.