Pirie Street is a road on the east side of the centre of Adelaide, the capital of South Australia. It runs east-west, between East Terrace and King William Street. After crossing King William Street, it continues as Waymouth Street. It forms the southern boundary of Hindmarsh Square which is in the centre of the north-east quadrant of the city centre.
Pirie Street was named after Sir John Pirie, Lord Mayor of London, England and a founding director of the South Australian Company. It is one of the narrower streets of the Adelaide grid, at 1ch wide.
Pirie Street is served by a stop on the Glenelg tramline on King William Street. It is mainly occupied by office buildings, restaurants, and nightspots.
The Pirie Street Methodist Church was located on the site that is now the Adelaide Town Hall office building, with the 1862 Methodist Meeting Hall behind. The Adelaide City Council headquarters are on Pirie Street.