Örbyhus Castle is a castle in Tierp Municipality, Sweden. It lies some 12 kilometres east of European route E4, approximately halfway between Uppsala and Gävle.
Known since the 14th century, the estate was turned into a castle during the 15th century by Johan Kristensson Vasa, grandfather of Swedish king Gustav Vasa. The castle has been used as a prison, and its most well-known prisoner was king Eric XIV of Sweden, who died here in 1577.