The Midtown Exchange is a large commercial building located in the Midtown Phillips neighborhood, in Minneapolis, Minnesota, United States. It is the second-largest building in Minnesota in terms of leasable space, after the Mall of America. It was built in 1928 as a retail and mail-order catalog facility for Sears, which occupied it until 1994. It lay vacant until 2005, when it was transformed into multipurpose commercial space.
The building is listed on the National Register of Historic Places as the Sears, Roebuck and Company Mail-Order Warehouse and Retail Store.