Sambuca di Sicilia (Sicilian: Sammuca) is a comune (municipality) in the Province of Agrigento in the Italian region Sicily, located about 68km southwest of Palermo and about 89km northwest of Agrigento. Sambuca di Sicilia borders the following municipalities: Bisacquino, Caltabellotta, Contessa Entellina, Giuliana, Menfi, Santa Margherita di Belice, Sciacca.
